Cbcb:Pop-Lab:Niranjan-Report: Difference between revisions

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-==March 2nd, 2009==
-===Tasks===
-# Made more updates to my webpage
-# Started making a presentation for my job talk
-# Assisted Carl in writing a grant proposal to extend on our work on reassortments in the Flu genome.
-===Papers Read===
-# [http://www3.interscience.wiley.com/cgi-bin/fulltext/119423402/PDFSTART|Non-random reassortment in human influenza A viruses]
-R. Rabadan, A.J. Levine and M. Krasnitz.
-The basic idea in this paper is that if you assume constant
-rate of mutational drift in different segments of the same strain (an
-assumption that seems to be true on a coarse level for some segments, but
-not for others) then given two non-reassorted strains the nucleotide
-differences between their NA segments should be roughly proportional to
-that from the HA segments and they use that as a test to identify putative
-reassortments. They use a vaguely described idea to figure out which
-combination of segments have reassorted (probably done manually) and they
-seem to make no attempt to figure out if a set of taxa have reassorted
-based on a common event. Finally, there is no evaluation of the capability
-of this method, just a list of results which seem to clearly miss the
-reassortments we already know of! In fact they make the claim that they
-find all the reassortments from earlier works, in the abstract!

Latest revision as of 14:00, 6 April 2009