|
|
Line 1: |
Line 1: |
| ==March 2nd, 2009==
| |
|
| |
|
| ===Tasks===
| |
|
| |
| # Made more updates to my webpage
| |
| # Started making a presentation for my job talk
| |
| # Assisted Carl in writing a grant proposal to extend on our work on reassortments in the Flu genome.
| |
|
| |
| ===Papers Read===
| |
|
| |
| # [[Media:rabadan2007.pdf|Non-random reassortment in human influenza A viruses]]. R. Rabadan, A.J. Levine and M. Krasnitz.
| |
|
| |
| The basic idea in this paper is that if you assume constant
| |
| rate of mutational drift in different segments of the same strain (an
| |
| assumption that seems to be true on a coarse level for some segments, but
| |
| not for others), then given two non-reassorted strains, the nucleotide
| |
| differences between their NA segments should be roughly proportional to
| |
| that from the HA segments and they use that as a test to identify putative
| |
| reassortments. They use a vaguely described idea to figure out which
| |
| combination of segments have reassorted (probably done manually) and they
| |
| seem to make no attempt to figure out if a set of taxa have reassorted
| |
| based on a common event. Finally, there is no evaluation of the capability
| |
| of this method - just a list of results which seem to clearly miss the
| |
| reassortments we already know of. In fact, in the abstract, they make the
| |
| claim that they find all the reassortments from earlier works.
| |