Metagenoms
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Links
- JGI FAMeS
- JGI SIMHC
- Human Microbiome Project @ NIH
- {http://www.nature.com/nature/journal/v449/n7164/full/nature06244.html HMP Nature article Oct 2007]
HMP
- ~10X more bateria than human cells in the body
- small-subunit (16S) ribosomal RNA gene-sequence-based surveys :
- found in all microorganisms - has enough sequence conservation for accurate alignment - has enough variation for phylogenetic analyses.
- skin, mouth, oesophagus, stomach, colon and vagina
- largest reported data sets are for the gut
- most of the 10–100 trillion microorganisms in the human gastrointestinal tract live in the colon.
- more than 90% of all phylogenetic types (phylotypes) of colonic bacteria belong to just 2 of the 70 known divisions (phyla) in the domain Bacteria: the Firmicutes and the Bacteroidetes.