Dpuiu definitions

• Sensitivity and specificity

 Sensitivity=TP/(TP+FN)
 Specificity=TN/(TN+FP)
 
                   status      
 outcome           +    -
 +                 TP   FP
 -                 FN   TN
 
 FP: Type I error (P value)
 FN: Type II error
 
 try to minimize FP => increase specificity 
 Sensitive: align as many reads as possible
 Specific:  avoid misalignments

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• Functional genomics
• Molecular biology

• Ribosomal Database Project

• IS elemets

• Yeast two hybrid , Link

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• Purine:AG 2 rings => bigger
• Pyrimidine:CT 1 ring
• Transition Purine:Purine or Pyrimidine:Pyrimidine ; 2/3 of the snps
• Transversion Purine:Pyrimidine or Pyrimidine:Purine ; 1/3 or the snps

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• MSA
• Phylogenetic tree

• GO

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• Immunity
• MIC
• Horizontal gene transfer
• Gene therapy
• Wild type typical form of an organism, strain, gene, or characteristic as it occurs in nature; most common phenotype
• Gram-negative bacteria cell walls has an outer membrane; many are pathogenic

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• Decision_tree

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• Machine learning
• Random forest
• Neural network

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• Cross validation

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• Genome project

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• Obligate intracellular parasite

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• Q20: the number of bases in a read that have a quality value greater than 20; quality value of 20, there is a 1 in 100 chance that the base has been misidentified